QSAR Study of 3-Phenylamino-1,4-naphtoquinones Anti-cancer Activities

Ali, L and Saeed, A (2016) QSAR Study of 3-Phenylamino-1,4-naphtoquinones Anti-cancer Activities. International Research Journal of Pure and Applied Chemistry, 13 (3). pp. 1-6. ISSN 22313443

[thumbnail of Ali1332016IRJPAC30468-F.pdf] Text
Ali1332016IRJPAC30468-F.pdf - Published Version
Download (228kB)

Abstract

Aims: Evaluation the impact of quinones containing alkylamio groups upon biological activities and extent of napthoquinones based upon QSAR technique.

Study Design: QSAR Approach.

Place and Duration of Study: Data were collected from literature.

Methodology: About eleven naphthoquinones which have cytotoxic effect against DU145 Cancerous, MCF7 Cancerous and T24 Cancerous and 6 descriptors were used to find good QSAR model.

Results: The biological activity and surface tension of aminophenylnaphthoquinones can be modeled with linear regression with negative coefficient and satisfied statistical data for DU145 Cancerous r2=0.662, F=17.646, and s=0.34033

Conclusion: The inhabitation of DU145 Cancerous is influenced by surface tension.

Item Type: Article
Subjects: Library Eprints > Chemical Science
Depositing User: Managing Editor
Date Deposited: 18 May 2023 04:49
Last Modified: 17 Jan 2024 03:55
URI: http://scholar.sdpublishers.info/id/eprint/1992

Actions (login required)

View Item
View Item